Accordion Crimes is a difficult book to place in a single time period because the story takes place over about 100 years, originating in a small Sicilian village, but the main setting and focus is the United States.
The various settings introduced in the book influenced the characters in various ways, but one instance of influence was great enough to cause his death. The accordion maker was literally ruled over by his setting. The setting around him was one of oppression that worked against him because he was Sicilian. "… The accordion maker saw the approaching men with searing clarity, the loose thread on a coat, mud-spattered trouser legs, a logging chain in a big hand, the red shine of the engorged faces, a man with one blue eye and one yellow eye. Even then he hoped to be saved. He was innocent!
Pinse held his revolver loosely in his hand, had lost his staff in the rush up the stairs, so crowded it had been, looked at the Sicilians knotted in the corner...